Transgenerational epigenetic inheritance Addiction

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epigenetic genes , products (e.g., proteins) key components through environmental influences can affect genes of individual; serve mechanism responsible transgenerational epigenetic inheritance of behavioral phenotypes, phenomenon in environmental influences on genes of parent can affect associated traits , behavioral phenotypes of offspring (e.g., behavioral responses environmental stimuli). in addiction, epigenetic mechanisms play central role in pathophysiology of disease; has been noted of alterations epigenome arise through chronic exposure addictive stimuli during addiction can transmitted across generations, in turn affecting behavior of 1 s children (e.g., child s behavioral responses addictive drugs , natural rewards). more research needed determine specific epigenetic mechanisms , nature of heritable behavioral phenotypes arise addictions in humans. based upon preclinical evidence lab animals, addiction-related behavioral phenotypes transmitted across generations may serve increase or decrease child s risk of developing addiction.








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