Research Addiction

research indicates vaccines utilize anti-drug monoclonal antibodies can mitigate drug-induced positive reinforcement preventing drug moving across blood–brain barrier; however, current vaccine-based therapies effective in relatively small subset of individuals. of november 2015, vaccine-based therapies being tested in human clinical trials treatment addiction , preventative measure against drug overdoses involving nicotine, cocaine, , methamphetamine.

since addiction involves abnormalities in glutamate , gabaergic neurotransmission, receptors associated these neurotransmitters (e.g., ampa receptors, nmda receptors, , gabab receptors) potential therapeutic targets addictions. n-acetylcysteine, affects metabotropic glutamate receptors , nmda receptors, has shown benefit in preclinical , clinical studies involving addictions cocaine, heroin, , cannabinoids. may useful adjunct therapy addictions amphetamine-type stimulants, more clinical research required.

current medical reviews of research involving lab animals have identified drug class – class histone deacetylase inhibitors – indirectly inhibits function , further increases in expression of accumbal Δfosb inducing g9a expression in nucleus accumbens after prolonged use. these reviews , subsequent preliminary evidence used oral administration or intraperitoneal administration of sodium salt of butyric acid or other class hdac inhibitors extended period indicate these drugs have efficacy in reducing addictive behavior in lab animals have developed addictions ethanol, psychostimulants (i.e., amphetamine , cocaine), nicotine, , opiates; however, of august 2015 no clinical trials involving human addicts , hdac class inhibitors have been conducted test treatment efficacy in humans or identify optimal dosing regimen.

gene therapy option treat addiction.

this done increasing brain level of receptors dopamine (via d2 receptor).

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